Title : Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

Pub. Date : 2002 Oct

PMID : 12392761






7 Functional Relationships(s)
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1 The recombinant human ADAM-TS5, like ADAM-TS4 cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
2 The recombinant human ADAM-TS5, like ADAM-TS4 cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
3 The recombinant human ADAM-TS5, like ADAM-TS4 cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
4 The recombinant human ADAM-TS5, like ADAM-TS4 cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
5 The recombinant human ADAM-TS5, like ADAM-TS4 cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
6 In addition, ADAM-TS5 exhibited an additional site of cleavage in the region spanning residues Gly(1481) and Glu(1667), representing a unique cleavage of ADAM-TS5. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens
7 In addition, ADAM-TS5 exhibited an additional site of cleavage in the region spanning residues Gly(1481) and Glu(1667), representing a unique cleavage of ADAM-TS5. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens