Title : Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.

Pub. Date : 2002 Oct 15

PMID : 12388598






2 Functional Relationships(s)
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1 We report here that both dopamine (DA) D1 (SKF38393) and D2 (quinpirole) agonist treatments rapidly increase, in primary striatal neurons in culture, phosphorylation levels of Akt on Thr(308), a residue that is critically involved in its kinase activity. Quinpirole AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, overexpression of a mutant form of Akt that cannot be activated impaired cAMP response element-binding protein (CREB) phosphorylation induced by SKF38393 and quinpirole treatments. Quinpirole AKT serine/threonine kinase 1 Homo sapiens