Title : Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells.

Pub. Date : 2002 Sep

PMID : 12349896






2 Functional Relationships(s)
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1 Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFalpha-activatedA549 cells with concomitant inhibition of NF-kappaB mediated signaling cascades. amentoflavone mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role. amentoflavone mitochondrially encoded cytochrome c oxidase II Homo sapiens