Pub. Date : 2002 Sep 27
PMID : 12323385
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | However, pretreatment with the selective PKC inhibitor, calphostin-C significantly antagonized the corticosterone hypersecretion in morphine-withdrawn rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | Our results might indicate that expression of morphine dependence for hypothalamus-pituitary-adrenocortical axis hyperactivity involves PKC but not PKA signaling mechanisms. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | It is suggested that in rats PKC may be up-regulated during morphine dependence. | Morphine | protein kinase C, gamma | Rattus norvegicus |