Title : Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions.

Pub. Date : 2002 Oct

PMID : 12297547






5 Functional Relationships(s)
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1 Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions. Genistein estrogen receptor 1 (alpha) Mus musculus
2 Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions. Genistein estrogen receptor 1 (alpha) Mus musculus
3 Genistein treatment caused a dramatic increase in ERalpha in granulosa cells. Genistein estrogen receptor 1 (alpha) Mus musculus
4 Genistein-treated ERbeta knockout mice showed a similar induction of ERalpha, which is seen in CD-1 mice, suggesting that ERbeta does not mediate this effect. Genistein estrogen receptor 1 (alpha) Mus musculus
5 Similar ERalpha induction in granulosa cells was seen in CD-1 mice treated with lavendustin A, a tyrosine kinase inhibitor that has no known estrogenic actions, which suggests that this property of genistein may be responsible. Genistein estrogen receptor 1 (alpha) Mus musculus