Title : SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.

Pub. Date : 2002 Oct 1

PMID : 12234612






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 After a 24-hr treatment with 5 microM SU9516, cyclin D1 and cdk2 levels decreased by 10-60%. SU 9516 cyclin D1 Homo sapiens
2 These findings delineate a previously undescribed mechanism for SU9516-mediated cell growth arrest through down-regulation of cyclin D1, inhibition of cdk2 levels and activity, and pan-sequestration of E2F. SU 9516 cyclin D1 Homo sapiens