Title : Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans.

Pub. Date : 2002 Sep

PMID : 12231541






1 Functional Relationships(s)
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1 ET743 was metabolized by cDNA-expressed human CYP3A4 and to a much lesser extent by CYP2C9, CYP2D6, and CYP2E1 preparations. Trabectedin cytochrome P450 family 2 subfamily D member 6 Homo sapiens