Pub. Date : 2002 Sep 19
PMID : 12226745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. | purvalanol B | interferon induced protein 44 | Homo sapiens |
| 2 | In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction. | purvalanol B | interferon induced protein 44 | Homo sapiens |
| 3 | When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner. | purvalanol B | interferon induced protein 44 | Homo sapiens |
| 4 | We conclude that the anti-proliferative properties of purvalanol are mediated by inhibition of both p42/p44 MAPK and CDKs. | purvalanol B | interferon induced protein 44 | Homo sapiens |