Title : Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion.

Pub. Date : 2002 Sep 11

PMID : 12220664






3 Functional Relationships(s)
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1 Both ERK and caspase activation were blocked in cells depleted of polyamines by the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO). Eflornithine ornithine decarboxylase, structural 1 Mus musculus
2 Both ERK and caspase activation were blocked in cells depleted of polyamines by the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO). Eflornithine ornithine decarboxylase, structural 1 Mus musculus
3 Ornithine decarboxylase activity decreased after etoposide, indicating that DFMO exerts its effect by depleting cellular polyamines before induction of apoptosis. Eflornithine ornithine decarboxylase, structural 1 Mus musculus