Title : Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen.

Pub. Date : 2002 Nov 15

PMID : 12213816






3 Functional Relationships(s)
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1 We report that two alternate signaling pathways of protein kinase C (PKC) activation involving either the lipid second messengers (diacylglycerol and its mimetics, the phorbol esters) or reactive oxygen converge at the zinc finger of the regulatory domain. Diglycerides proline rich transmembrane protein 2 Homo sapiens
2 We report that two alternate signaling pathways of protein kinase C (PKC) activation involving either the lipid second messengers (diacylglycerol and its mimetics, the phorbol esters) or reactive oxygen converge at the zinc finger of the regulatory domain. Diglycerides proline rich transmembrane protein 2 Homo sapiens
3 Furthermore, purified recombinant PKC protein fragments shed stoichiometric amounts of Zn(2+) upon reaction with diacylglycerol, phorbol ester, or reactive oxygen in vitro. Diglycerides proline rich transmembrane protein 2 Homo sapiens