Pub. Date : 2002 Sep 1
PMID : 12202948
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies using mostly ex vivo systems suggested diphenylamine-2-carboxylate (DPC), 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and glybenclamide inhibit CFTR Cl- conductance (CFTR GCl). | 5-nitro-2-(3-phenylpropylamino)benzoic acid | CF transmembrane conductance regulator | Homo sapiens |
| 2 | Studies using mostly ex vivo systems suggested diphenylamine-2-carboxylate (DPC), 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and glybenclamide inhibit CFTR Cl- conductance (CFTR GCl). | 5-nitro-2-(3-phenylpropylamino)benzoic acid | CF transmembrane conductance regulator | Homo sapiens |
| 3 | At a concentration of 10(-4) M, NPPB, DPC, glybenclamide, and DIDS were equipotent and blocked approximately 50% of irreversibly phosphorylated and ATP-activated CFTR GCl (DIDS = 49 +/- 10% > NPPB = 46 +/- 10% > DPC = 38 +/- 7% > glybenclamide = 34 +/- 5%; values are mean +/- SE expressed as % inhibition from the control). | 5-nitro-2-(3-phenylpropylamino)benzoic acid | CF transmembrane conductance regulator | Homo sapiens |