Title : Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.

Pub. Date : 2002 Dec 10

PMID : 12200548






1 Functional Relationships(s)
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1 Using this method, a total of 25 benzothiazole derivatives that inhibit huntingtin fibrillogenesis in a dose-dependent manner were discovered from a library of approximately 184,000 small molecules. benzothiazole huntingtin Homo sapiens