Title : Predicting evolution by in vitro evolution requires determining evolutionary pathways.

Pub. Date : 2002 Sep

PMID : 12183265

1 Functional Relationships(s)
Compound Name
Protein Name
1 In an early example of DNA shuffling, Stemmer (W. P. C. Stemmer, Nature 370:389-390, 1994) demonstrated a dramatic improvement in the activity of the TEM-1 beta-lactamase toward cefotaxime as the consequence of six amino acid substitutions. Cefotaxime CD248 molecule Homo sapiens