Pub. Date : 2002 Sep 6
PMID : 12183047
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MPTP (20 mg/kg, subcutaneously) was injected daily into COX-1- and COX-2-deficient mice and wild-type (WT) controls for five consecutive days. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 2 | These results indicate that loss of COX-2 activity reduces MPTP-induced damage to the dopaminergic neurons of the SNc, but does not alter the levels of dopamine and its metabolites in the striatum. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 3 | Interestingly, MPTP caused the same degree of loss of dopaminergic neurons in both COX-2(+/-) and COX-2(-/-) mice (20% loss). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 4 | Interestingly, MPTP caused the same degree of loss of dopaminergic neurons in both COX-2(+/-) and COX-2(-/-) mice (20% loss). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 5 | The results of this study indicate an important role of COX-2 in MPTP-induced neuronal degeneration and suggest the possibility that manipulation of the COX-2 could be an important target for therapeutic interventions in PD. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |
| 6 | The results of this study indicate an important role of COX-2 in MPTP-induced neuronal degeneration and suggest the possibility that manipulation of the COX-2 could be an important target for therapeutic interventions in PD. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | cytochrome c oxidase II, mitochondrial | Mus musculus |