Title : Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

Pub. Date : 2002 Sep

PMID : 12181437






1 Functional Relationships(s)
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1 Determination of intrinsic clearances predicts that hepatic UGT1A1 and UGT1A9 and the extrahepatic UGT1A7 are major components in SN-38-G formation, whereas a minor role is suggested for UGT1A6, UGT1A8, and UGT1A10. Irinotecan UDP glucuronosyltransferase family 1 member A7 Homo sapiens