Title : Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants.

Pub. Date : 2002 Jul

PMID : 12161073






1 Functional Relationships(s)
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1 Two other residues, Lys 114 and Arg 129, then cooperate with Lys 125 to induce the low-affinity complex into an activated, high-affinity complex, in which a network of electrostatic interactions between antithrombin and the entire pentasaccharide is established. Arginine serpin family C member 1 Homo sapiens