Title : Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts.

Pub. Date : 2002 Oct 4

PMID : 12151388






4 Functional Relationships(s)
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1 Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited. Tetradecanoylphorbol Acetate Kirsten rat sarcoma viral oncogene homolog Mus musculus
2 In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13. Tetradecanoylphorbol Acetate Kirsten rat sarcoma viral oncogene homolog Mus musculus
3 In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13. Tetradecanoylphorbol Acetate Kirsten rat sarcoma viral oncogene homolog Mus musculus
4 In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13. Tetradecanoylphorbol Acetate Kirsten rat sarcoma viral oncogene homolog Mus musculus