Title : Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site.

Pub. Date : 2002 Oct 4

PMID : 12149252






1 Functional Relationships(s)
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1 Additional studies revealed that the internal salt bridge (Ile(16)-Asp(194)) of factor Xa(Y225P) is partially destabilized, a process that is reversible upon occupation of the S1 site. Aspartic Acid coagulation factor X Homo sapiens