Title : Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.

Pub. Date : 2002 Aug 1

PMID : 12140766






1 Functional Relationships(s)
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1 Moreover, while PR3 is involved in the cleavage of caspase-3, PR3-mediated DOX-induced DNA fragmentation and apoptosis were not prevented by a specific inhibitor of caspase-3. Doxorubicin caspase 3 Homo sapiens