Title : Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes.

Pub. Date : 2002

PMID : 12138244






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RNase protection assay showed a negative correlation between bcl-x(L) and mcl-1 mRNA expression levels and the sensitivity to 5-FU and gemcitabine after 5-FU and gemcitabine treatment. Fluorouracil BCL2 like 1 Homo sapiens
2 RNase protection assay showed a negative correlation between bcl-x(L) and mcl-1 mRNA expression levels and the sensitivity to 5-FU and gemcitabine after 5-FU and gemcitabine treatment. Fluorouracil BCL2 like 1 Homo sapiens
3 The bax/bcl-2 ratio is predictive of chemotherapy sensitivity, whereas bcl-x(L) and mcl-1 mRNA levels following repeated exposure to 5-FU or gemcitabine are associated with resistance to these drugs. Fluorouracil BCL2 like 1 Homo sapiens