Pub. Date : 2002 Jul
PMID : 12136890
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 suppresses nuclear factor-kappaB mediated interleukin 15 production in rheumatoid synoviocytes. | Dinoprostone | interleukin 15 | Homo sapiens |
| 2 | RESULTS: PGE2 at concentrations from 10(-11) to 10(-5) M inhibited secretion of IL-15 by FLS, while increasing IL-10 production, in a dose dependent manner. | Dinoprostone | interleukin 15 | Homo sapiens |
| 3 | IL-15 production stimulated by interferon-gamma (IFN-gamma), IL-1beta, or lipopolysaccharide were also strongly inhibited by PGE2. | Dinoprostone | interleukin 15 | Homo sapiens |
| 4 | This PGE2-mediated inhibition of IL-15 production appears to be dependent in part on the increase of IL-10, since neutralizing anti-IL-10 antibodies reversed this inhibition to some extent. | Dinoprostone | interleukin 15 | Homo sapiens |
| 5 | The EMSA of the NF-kappaB site in the IL-15 promoter showed that PGE2 inhibited binding of NF-kappaB in a dose dependent manner. | Dinoprostone | interleukin 15 | Homo sapiens |
| 6 | Experiments using inducers and an inhibitor of cyclic AMP (cAMP) suggest that a major intracellular signal mediates the regulatory effect of PGE2 on the production of IL-15 and IL-10. | Dinoprostone | interleukin 15 | Homo sapiens |
| 7 | CONCLUSION: PGE2 differentially regulates the production of IL-15 and IL-10 in FLS. | Dinoprostone | interleukin 15 | Homo sapiens |
| 8 | The strong inhibition of PGE2 on IL-15 production is exerted via a cAMP-dependent modulation of NF-kappaB activity. | Dinoprostone | interleukin 15 | Homo sapiens |