Title : Cysteine 116 participates in intermolecular bonding of the human VEGF(121) homodimer.

Pub. Date : 2002 Aug 1

PMID : 12127077






2 Functional Relationships(s)
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1 In this study, we determined that human VEGF(121) contains a third interchain disulfide bond between Cys116 of each monomer. Disulfides vascular endothelial growth factor A Homo sapiens
2 In fact, selective reduction of the Cys116 interchain disulfide bond yielded an unstable VEGF(121) molecule, which reoxidized quickly. Disulfides vascular endothelial growth factor A Homo sapiens