Title : One pot synthesis of nitrogen-containing polycyclic delta-lactones by double nucleophilic addition of bis(trimethylsilyl)ketene acetals to pyridines.

Pub. Date : 2002 May 7

PMID : 12123058






1 Functional Relationships(s)
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1 Pyridine and bis(TMS)ketene acetals (TMS = trimethylsilyl) react successively with methylchloroformate and iodine (or peracids) to give, via functionalized dihydropyridines, bicyclic nitrogen-containing lactones which have been characterized by X-ray crystallography. pyridine PYD and CARD domain containing Homo sapiens