Title : Ran binds to chromatin by two distinct mechanisms.

Pub. Date : 2002 Jul 9

PMID : 12121625






2 Functional Relationships(s)
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1 The latter functions rely on the presence of high local concentrations of GTP-bound Ran near mitotic chromatin. Guanosine Triphosphate RAN, member RAS oncogene family Homo sapiens
2 RanGTP localization has been proposed to result from the association of Ran"s GDP/GTP exchange factor, RCC1, with chromatin, but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes. Guanosine Triphosphate RAN, member RAS oncogene family Homo sapiens