Title : Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia.

Pub. Date : 2002

PMID : 12111653






1 Functional Relationships(s)
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Protein Name
Organism
1 The Asn822(Lys) mutation affects a highly conserved codon within the tyrosine kinase activation loop leading, likewise the Asp(816) mutants, to constitutive ligand-independent activation of the KIT receptor. Aspartic Acid KIT proto-oncogene, receptor tyrosine kinase Homo sapiens