Title : NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells.

Pub. Date : 2002 Aug

PMID : 12107048






1 Functional Relationships(s)
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1 NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs). Clonidine solute carrier family 9 member C1 Homo sapiens