Pub. Date : 2002 Sep 13
PMID : 12097324
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. | Triglycerides | angiopoietin-like 3 | Mus musculus |
| 2 | To elucidate the regulatory mechanism of ANGPTL3 on lipid metabolism, we focused on the metabolic pathways of triglyceride in the present study. | Triglycerides | angiopoietin-like 3 | Mus musculus |
| 3 | Overexpression of Angptl3 in KK/San mice resulted in a marked increase of triglyceride-enriched very low density lipoprotein (VLDL). | Triglycerides | angiopoietin-like 3 | Mus musculus |
| 4 | These data strongly support the hypothesis that ANGPTL3 is a new class of lipid metabolism modulator, which regulates VLDL triglyceride levels through the inhibition of LPL activity. | Triglycerides | angiopoietin-like 3 | Mus musculus |