Pub. Date : 2002 Sep 6
PMID : 12087089
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 2 | Carbohydrate response element-binding protein (ChREBP) was recently shown to regulate the glucose responsiveness of the L-PK promoter activity in hepatocytes. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 3 | Carbohydrate response element-binding protein (ChREBP) was recently shown to regulate the glucose responsiveness of the L-PK promoter activity in hepatocytes. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 4 | Glucose stimulates ChREBP transcription in INS-1 cells, as shown by nuclear run-on experiments. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 5 | Overexpression of ChREBP in INS-1 cells using the tet-on system results in a left shift of glucose responsiveness of L-PK expression and an enhanced L-PK promoter activity. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 6 | Both endogenous and doxycycline-induced ChREBP proteins bind to the L-PK promoter in a glucose-dependent manner. | Glucose | MLX interacting protein-like | Rattus norvegicus |
| 7 | These unprecedented results suggest that ChREBP rather than USF mediates glucose-promoted L-PK expression in insulin-secreting cells. | Glucose | MLX interacting protein-like | Rattus norvegicus |