Pub. Date : 2002 Jul
PMID : 12086935
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 2 | We recently reported that AMPK is activated by metformin in cultured rat hepatocytes, mediating the inhibitory effects of the drug on hepatic glucose production. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 3 | In the present study, we evaluated whether therapeutic doses of metformin increase AMPK activity in vivo in subjects with type 2 diabetes. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 4 | Metformin treatment for 10 weeks significantly increased AMPK alpha2 activity in the skeletal muscle, and this was associated with increased phosphorylation of AMPK on Thr172 and decreased acetyl-CoA carboxylase-2 activity. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 5 | Metformin treatment for 10 weeks significantly increased AMPK alpha2 activity in the skeletal muscle, and this was associated with increased phosphorylation of AMPK on Thr172 and decreased acetyl-CoA carboxylase-2 activity. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 6 | The increase in AMPK alpha2 activity was likely due to a change in muscle energy status because ATP and phosphocreatine concentrations were lower after metformin treatment. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 7 | Metformin-induced increases in AMPK activity were associated with higher rates of glucose disposal and muscle glycogen concentrations. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 8 | These findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |