Pub. Date : 2002 Sep 6
PMID : 12082110
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN. | Glycine | vitronectin | Homo sapiens |
| 2 | Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1. | Glycine | vitronectin | Homo sapiens |