Title : Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.

Pub. Date : 2002 Sep 6

PMID : 12077145






4 Functional Relationships(s)
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1 To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2. Sterols Upc2p Saccharomyces cerevisiae S288C
2 To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous sterol due to a neomorphic mutation in the transcription factor, UPC2. Sterols Upc2p Saccharomyces cerevisiae S288C
3 We identified 9 genes as responsive to UPC2 that were also induced under anaerobiosis, when sterol uptake is essential. Sterols Upc2p Saccharomyces cerevisiae S288C
4 UPC2 itself was up-regulated under these conditions and was required for aerobic sterol influx. Sterols Upc2p Saccharomyces cerevisiae S288C