Title : The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).

Pub. Date : 2002 Aug 30

PMID : 12070164






1 Functional Relationships(s)
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1 This interaction is enhanced by the small GTPase Ran in its activated GTP-bound form and also by a double mutation in APC-(129-250), which deletes two amino acids forming two of the major interhelical interactions within the coiled coil. Guanosine Triphosphate RAN, member RAS oncogene family Homo sapiens