Title : Real-time monitoring of P-glycoprotein activation in living cells.

Pub. Date : 2002 Jun 25

PMID : 12069596






2 Functional Relationships(s)
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1 The kinetic constants [concentration of half-maximum activation (inhibition), K(i), and the maximum (minimum) transporter activity, V(i)] were in qualitative and quantitative agreement with those determined earlier for Pgp-ATPase activation monitored by phosphate release in inside-out cellular vesicles and in purified reconstituted systems, respectively. Phosphates dynein, axonemal, heavy chain 8 Mus musculus
2 The micro-pH measurements provide for the first time direct evidence for a tight coupling between the rate of extracellular proton extrusion and intracellular phosphate release upon Pgp-ATPase activation. Phosphates dynein, axonemal, heavy chain 8 Mus musculus