Title : An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1.

Pub. Date : 2002 Jun 17

PMID : 12065410






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We demonstrate that the conversion of a specific glutamate residue (E306) to an alanine in this region locks TREK-1 in the open configuration and abolishes the cAMP/PKA down-modulation. Tocopherols potassium two pore domain channel subfamily K member 2 Homo sapiens
2 We conclude that protonation of E306 tunes the TREK-1 mechanical setpoint and thus sets lipid sensitivity. Tocopherols potassium two pore domain channel subfamily K member 2 Homo sapiens