Title : Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product.

Pub. Date : 2002 Jun

PMID : 12063468






5 Functional Relationships(s)
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1 Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product. Oligonucleotides BCL2 like 1 Homo sapiens
2 Untreated cells and bcl-xl sense oligonucleotides were controls. Oligonucleotides BCL2 like 1 Homo sapiens
3 RESULTS: Bcl-xl protein expression after antisense oligonucleotides was downwardly regulated in both cell lines relative to sense oligonucleotides (>65%). Oligonucleotides BCL2 like 1 Homo sapiens
4 RESULTS: Bcl-xl protein expression after antisense oligonucleotides was downwardly regulated in both cell lines relative to sense oligonucleotides (>65%). Oligonucleotides BCL2 like 1 Homo sapiens
5 CONCLUSION: Antisense oligonucleotides directed at the bcl-xl gene product engender apoptosis in mesothelioma cell lines. Oligonucleotides BCL2 like 1 Homo sapiens