Title : In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.

Pub. Date : 2002 Jun

PMID : 12061540






1 Functional Relationships(s)
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1 To investigate the effects of KTZ on CYP metabolic activities, 7-ethoxyresorufin, tolbutamide, bufuralol, and midazolam hydrochloride were used as specific substrates for CYP1A1/2, CYP2C21, CYP2D15, and CYP3A12, respectively. Midazolam cytochrome P450 2C21 Canis lupus familiaris