Title : The ligand-binding site of bovine beta-lactoglobulin: evidence for a function?

Pub. Date : 2002 May 10

PMID : 12054801






3 Functional Relationships(s)
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Protein Name
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1 Ever since the fortuitous observation that beta-lactoglobulin (beta-Lg), the major whey protein in the milk of ruminants, bound retinol, the details of the binding have been controversial. Vitamin A beta-lactoglobulin Bos taurus
2 Ever since the fortuitous observation that beta-lactoglobulin (beta-Lg), the major whey protein in the milk of ruminants, bound retinol, the details of the binding have been controversial. Vitamin A beta-lactoglobulin Bos taurus
3 We have now determined the crystal structures of the complexes of the trigonal form of beta-Lg at pH 7.5 with bound retinol (R=21.4% for 7329 reflections between 20 and 2.4 A resolution, R(free)=30.6%) and with bound retinoic acid (R=22.7% for 7813 reflections between 20 and 2.34 A resolution, R(free)=29.8%). Vitamin A beta-lactoglobulin Bos taurus