Title : Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.

Pub. Date : 2002

PMID : 12049174






2 Functional Relationships(s)
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1 In wild type animals, pretreatment with the CAR inverse agonist androstenol blocks the response of both the CYP2B10 and CYP3A11 genes to PB and TCPOBOP, and decreases basal CYP3A11 expression. Androstenols cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus
2 In wild type animals, pretreatment with the CAR inverse agonist androstenol blocks the response of both the CYP2B10 and CYP3A11 genes to PB and TCPOBOP, and decreases basal CYP3A11 expression. Androstenols cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus