Pub. Date : 2002 Apr 20
PMID : 12044562
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 2 | Skatole, a derivative of tryptophan, is produced in the hind-gut of pigs and is metabolised via hepatic cytochrome P4502E1 (CYP2E1). | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 3 | Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some pigs is a major cause of "boar taint" and is associated with defective expression of CYP2E1. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 4 | Skatole induced CYP2E1 protein expression to the same degree as did acetone, a known CYP2E1 inducer. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 5 | Skatole induced CYP2E1 protein expression to the same degree as did acetone, a known CYP2E1 inducer. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 6 | Induction of CYP2E1 by skatole was protein-synthesis dependent. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 7 | Androstenone antagonised the effect of skatole on CYP2E1 expression but did not affect the CYP2E1 protein level when added alone. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 8 | These results suggest that defective expression of CYP2E1 in some pigs is due to excessive concentrations of androstenone which prevent CYP2E1 induction by its substrate skatole. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |
| 9 | These results suggest that defective expression of CYP2E1 in some pigs is due to excessive concentrations of androstenone which prevent CYP2E1 induction by its substrate skatole. | Skatole | cytochrome P450 family 2 subfamily E member 1 | Sus scrofa |