Title : A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur.

Pub. Date : 2002 Jun

PMID : 12042667






2 Functional Relationships(s)
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1 Since cytochrome P450 2A6 (CYP2A6) has been reported to metabolize FT to yield 5-fluorouracil (5-FU), it was postulated that the poor metabolic phenotype of patient 1 was caused by mutations of the CYP2A6 gene. Tegafur cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 Since cytochrome P450 2A6 (CYP2A6) has been reported to metabolize FT to yield 5-fluorouracil (5-FU), it was postulated that the poor metabolic phenotype of patient 1 was caused by mutations of the CYP2A6 gene. Tegafur cytochrome P450 family 2 subfamily A member 6 Homo sapiens