Title : Role of basic residues of the autolysis loop in the catalytic function of factor Xa.

Pub. Date : 2002 May 28

PMID : 12022882






3 Functional Relationships(s)
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1 The reactivities of Arg(143) and Lys(147) mutants were improved approximately 2-fold with antithrombin in the absence but not in the presence of heparin cofactors. Arginine serpin family C member 1 Homo sapiens
2 On the other hand, the pentasaccharide-catalyzed reactivity of antithrombin with the Arg(150) mutant was impaired by an order of magnitude. Arginine serpin family C member 1 Homo sapiens
3 These results suggest that Arg(150) of the autolysis loop may specifically interact with the activated conformation of antithrombin. Arginine serpin family C member 1 Homo sapiens