Title : Comparison of the catalytic roles played by the KMSKS motif in the human and Bacillus stearothermophilus trosyl-tRNA synthetases.

Pub. Date : 2002 Aug 9

PMID : 12016229






2 Functional Relationships(s)
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1 In Bacillus stearothermophilus tyrosyl-tRNA synthetase, the KMSKS motif (230KFGKT234) has been shown to stabilize the transition state for tyrosine activation through interactions with the pyrophosphate moiety of ATP. kmsks tyrosyl-tRNA synthetase 1 Homo sapiens
2 In addition, although they play similar roles in catalysis, the overall contribution of the KMSKS motif to catalysis appears to be significantly less in human tyrosyl-tRNA synthetase than it is in the B. stearothermophilus enzyme. kmsks tyrosyl-tRNA synthetase 1 Homo sapiens