Title : Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A.

Pub. Date : 2002 May

PMID : 12010777






3 Functional Relationships(s)
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1 TSA rapidly induced H4 acetylation in IL-8 promoter chromatin, whereas caprylic acid did not. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens
2 These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens
3 These results suggest that the inhibition of IL-8 gene transcription induced by caprylic acid and TSA does not necessarily require the marked suppression of transcription factors, and the mechanism of inhibition of IL-8 gene transcription may be different between caprylic acid and TSA. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens