Title : Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death.

Pub. Date : 2002 May

PMID : 12000740

2 Functional Relationships(s)
Compound Name
Protein Name
1 However, while GCLC cleavage is dependent on caspase-3, GSH extrusion occurs by a caspase-3-independent mechanism. Glutathione caspase 3 Homo sapiens
2 Our identification of GCLC as a target for caspase-3-dependent cleavage during apoptotic cell death suggests that this post-translational modification may represent a novel mechanism for regulating GSH biosynthesis during apoptosis. Glutathione caspase 3 Homo sapiens