Title : An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation.

Pub. Date : 2002 May 15

PMID : 11996574






1 Functional Relationships(s)
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1 Apart from its mechanistic implications, this atomic resolution structure affords an unusually detailed view of the structure, dynamics, and hydrogen-bonding networks of TEM-1, which may be useful for the design of inhibitors against this key antibiotic resistance target. Hydrogen CD248 molecule Homo sapiens