Title : SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells.

Pub. Date : 2002 May 15

PMID : 11994457






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Killer cell Ig-like receptors (KIR) are MHC class I-binding immunoreceptors that can suppress activation of human NK cells through recruitment of the Src homology 2-containing protein tyrosine phosphatase-1 (SHP-1) to two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens