Title : Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects.

Pub. Date : 2002 Apr

PMID : 11990872






1 Functional Relationships(s)
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1 Although a general immunosuppressant that affects both T- and B-cell function, cyclophosphamide has selective immune effects in MS by suppressing IL-12 and Th1-type responses and enhancing Th2/Th3 responses (IL-4, IL-10, TGF-beta; eosinophils in peripheral blood). Cyclophosphamide interleukin 4 Homo sapiens