Pub. Date : 2002 May 15
PMID : 11988095
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pancreatic beta-cells chronically exposed to fatty acids show higher carnitine palmitoyltransferase I (CPT I) protein levels, higher palmitate oxidation rates and an altered insulin response to glucose. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 2 | Pancreatic beta-cells chronically exposed to fatty acids show higher carnitine palmitoyltransferase I (CPT I) protein levels, higher palmitate oxidation rates and an altered insulin response to glucose. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 3 | The overexpression of CPT I in INS1E cells caused a more than a 5-fold increase in the levels of CPT I protein (detected by Western blotting), a 6-fold increase in the CPT activity, and an increase in fatty acid oxidation at 2.5 mM glucose (1.7-fold) and 15 mM glucose (3.1-fold). | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 4 | This decrease depended on CPT I activity, since the presence of etomoxir, a specific inhibitor of CPT I, in the preincubation medium normalized the CPT I activity, the fatty-acid oxidation rate and the insulin secretion in response to glucose. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 5 | This decrease depended on CPT I activity, since the presence of etomoxir, a specific inhibitor of CPT I, in the preincubation medium normalized the CPT I activity, the fatty-acid oxidation rate and the insulin secretion in response to glucose. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 6 | This decrease depended on CPT I activity, since the presence of etomoxir, a specific inhibitor of CPT I, in the preincubation medium normalized the CPT I activity, the fatty-acid oxidation rate and the insulin secretion in response to glucose. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 7 | They also indicate that up-regulation of CPT I contributes to the loss of response to high glucose in beta-cells exposed to fatty acids. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |