Title : Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

Pub. Date : 2002 Jul 5

PMID : 11986327






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As with others in this subgroup, the cytosolic domain of Siglec-11 is phosphorylated at tyrosine residue(s) upon pervanadate treatment of cells and then recruits the protein-tyrosine phosphatases SHP-1 and SHP-2. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens