Title : H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger.

Pub. Date : 2002 May

PMID : 11984519






2 Functional Relationships(s)
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1 At apical pH 6.5, and only in Na(+)-containing media, protein kinase A activation (by forskolin or vasoactive intestinal peptide) or selective NHE3 inhibition (by S1611) reduced transepithelial dipeptide transport and cellular accumulation by a reduction in the capacity (without effect on affinity) of dipeptide uptake. Dipeptides solute carrier family 9 member A3 Homo sapiens
2 At apical pH 6.5, and only in Na(+)-containing media, protein kinase A activation (by forskolin or vasoactive intestinal peptide) or selective NHE3 inhibition (by S1611) reduced transepithelial dipeptide transport and cellular accumulation by a reduction in the capacity (without effect on affinity) of dipeptide uptake. Dipeptides solute carrier family 9 member A3 Homo sapiens